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Effect of High-Fat Diet on Peripheral Neuropathy in C57BL6 Mice
Joint Authors
Xu, Lingling
Tang, Dou
Guan, Meiping
Xie, Cuihua
Xue, Yaoming
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Dyslipidemia may contribute to the development of peripheral neuropathy, even in prediabetics; however, few studies have evaluated vascular dysfunction and oxidative stress in patients with peripheral neuropathy.
Methods.
Using high-fat diet- (HFD-) induced prediabetic C57BL/6 mice, we assessed motor and sensory nerve conduction velocity (NCV) using a BIOPAC System and thermal algesia with a Plantar Test (Hargreaves’ method) Analgesia Meter.
Intraepidermal nerve fiber density and mean dendrite length were tested following standard protocols.
Vascular endothelial growth factor-A (VEGF-A) and 12/15-lipoxygenase (12/15-LOX) were evaluated by immunohistochemistry and Western blot, respectively.
Results.
HFD-fed mice showed deficits in motor and sensory NCV, thermal hyperalgesia, reduced mean dendrite length, and VEGF-A expression in the plantar skin and increased 12/15-LOX in the sciatic nerve ( P < 0.05 compared with controls).
Conclusion.
HFD may cause large myelinated nerve and small sensory nerve fiber damage, thus leading to neuropathy.
The mean dendrite length may be a more sensitive marker for early detection of peripheral neuropathy.
Reduced blood supply to the nerves and increased oxidative stress may contribute to the development and severity of peripheral neuropathy.
American Psychological Association (APA)
Xu, Lingling& Tang, Dou& Guan, Meiping& Xie, Cuihua& Xue, Yaoming. 2014. Effect of High-Fat Diet on Peripheral Neuropathy in C57BL6 Mice. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036454
Modern Language Association (MLA)
Xu, Lingling…[et al.]. Effect of High-Fat Diet on Peripheral Neuropathy in C57BL6 Mice. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036454
American Medical Association (AMA)
Xu, Lingling& Tang, Dou& Guan, Meiping& Xie, Cuihua& Xue, Yaoming. Effect of High-Fat Diet on Peripheral Neuropathy in C57BL6 Mice. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036454