Thermogenic Effect of Glucose in Hypothyroid Subjects
Joint Authors
Kozacz, Agnieszka
Grunt, Paulina
Steczkowska, Marta
Mikulski, Tomasz
Dąbrowski, Jan
Górecka, Monika
Sanocka, Urszula
Ziemba, Andrzej Wojciech
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The importance of thyroid hormone, catecholamines, and insulin in modification of the thermogenic effect of glucose (TEG) was examined in 34 healthy and 32 hypothyroid subjects.
We calculated the energy expenditure at rest and during oral glucose tolerance test.
Blood samples for determinations of glucose, plasma insulin, adrenaline (A), and noradrenaline (NA) were collected.
It was found that TEG was lower in hypothyroid than in control group ( 19.68 ± 3.90 versus 55.40 ± 7.32 kJ, resp., P < 0.0004 ).
Mean values of glucose and insulin areas under the curve were higher in women with hypothyroidism than in control group ( 286.79 ± 23.65 versus 188.41 ± 15.84 mmol/L·min, P < 0.003 and 7563.27 ± 863.65 versus 4987.72 ± 583.88 mU/L·min, P < 0.03 resp.).
Maximal levels of catecholamines after glucose ingestion were higher in hypothyroid patients than in control subjects (Amax— 0.69 ± 0.08 versus 0.30 ± 0.07 nmol/L, P < 0.0001 , and NAmax— 6.42 ± 0.86 versus 2.54 ± 0.30 nmol/L, P < 0.0002 ).
It can be concluded that in hypothyroidism TEG and glucose tolerance are decreased while the adrenergic response to glucose administration is enhanced.
Presumably, these changes are related to decreased insulin sensitivity and responsiveness to catecholamine action.
American Psychological Association (APA)
Kozacz, Agnieszka& Grunt, Paulina& Steczkowska, Marta& Mikulski, Tomasz& Dąbrowski, Jan& Górecka, Monika…[et al.]. 2014. Thermogenic Effect of Glucose in Hypothyroid Subjects. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036456
Modern Language Association (MLA)
Kozacz, Agnieszka…[et al.]. Thermogenic Effect of Glucose in Hypothyroid Subjects. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036456
American Medical Association (AMA)
Kozacz, Agnieszka& Grunt, Paulina& Steczkowska, Marta& Mikulski, Tomasz& Dąbrowski, Jan& Górecka, Monika…[et al.]. Thermogenic Effect of Glucose in Hypothyroid Subjects. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036456