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Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy
Joint Authors
Yu, Ling
Ding, Yiling
Huang, Ting
Huang, Xiaoxia
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine the correlation between maternal bile acid (BA) level and fetal pulmonary surfactant in rats and study the effects of BA on fetal lung in rat model of intrahepatic cholestasis of pregnancy.
Methods .
Forty pregnant rats were treated with (A) 5.5 mg/kg BA, (B) 1.4 mg/kg BA, and (C) 1 ml physiological saline.
Levels of total bile acid (TBA), ALT, AST, TBIL, DBIL, and SP-A were determined and the lungs of fetal rats were analyzed for pathological changes.
Results .
Groups A and B intervened with BA showed significant higher level of TBA in both maternal and fetal serum, more mortality rate of fetal rats, more concentration of SP-A in fetal serum, and wider alveolus mesenchyme of fetal rats than the control Group C.
Higher level of BA associated with increased fetal risk and lower numerical density of mitochondria in type II alveolar epithelial cells.
The levels of TBA in maternal serum were found to have significant positive correlation with those in fetal serum and SP-A level but negatively with the area of alveolus and the numerical density of lamellar body.
Conclusions.
The TBA level in maternal serum showed significant association with lung pathological changes in fetal rats.
American Psychological Association (APA)
Yu, Ling& Ding, Yiling& Huang, Ting& Huang, Xiaoxia. 2014. Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036457
Modern Language Association (MLA)
Yu, Ling…[et al.]. Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036457
American Medical Association (AMA)
Yu, Ling& Ding, Yiling& Huang, Ting& Huang, Xiaoxia. Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036457