Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture
Joint Authors
Fehrendt, Hinrich
Linn, Thomas
Hartmann, Sonja
Szalay, Gabor
Heiss, Christian
Schnettler, Reinhard
Lips, Katrin Susanne
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A correlation between obesity and bone metabolism is strongly assumed because adipocytes and osteoblasts originate from the same precursor cells and their differentiation is conversely regulated by the same factors.
It is controversially discussed if obesity protects bone or leads to loss of bone mass.
Thus, the aim of the present study was to investigate the influence of diet-induced mild obesity (11% increased body weight compared to control) on bone microstructure in mice.
Four-week-old male C57BL/6J mice received a high-fat diet (HFD, 60% kcal from fat) and were analyzed by means of dual X-ray absorptiometry, histological methods, real-time RT-PCR, and transmission electron microscopy in comparison to control animals (10% kcal from fat).
The cancellous bone mass, collagen 1 α 1 expression, amount of osteoid, and cohesion of cells via cell-to-cell contacts decreased in HFD mice whereas the bone mineral density and the amount of osteoblasts and osteoclasts were not modified.
The amount of apoptotic osteocytes was increased in HFD mice in comparison to controls.
We conclude that moderately increased body weight does not protect bone architecture from age-dependent degeneration.
By contrast, bone microstructure is negatively affected and reduced maintenance of cell-cell contacts may be one of the underlying mechanisms.
American Psychological Association (APA)
Fehrendt, Hinrich& Linn, Thomas& Hartmann, Sonja& Szalay, Gabor& Heiss, Christian& Schnettler, Reinhard…[et al.]. 2014. Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036465
Modern Language Association (MLA)
Fehrendt, Hinrich…[et al.]. Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036465
American Medical Association (AMA)
Fehrendt, Hinrich& Linn, Thomas& Hartmann, Sonja& Szalay, Gabor& Heiss, Christian& Schnettler, Reinhard…[et al.]. Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036465