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Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients
Joint Authors
Gu, Yulu
Liu, Xiaoli
Yu, Yaqin
Shi, Jieping
Ai, Lizhe
Sun, Hui
Kanu, Joseph Sam
Wang, Chong
Liu, Yawen
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions and is related to invasion and metastasis of malignancy.
The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males.
In this study, we want to investigate whether ATM polymorphisms are associated with gender-specific metastasis of PTC.
358 PTC patients in Northern China, including 109 males and 249 females, were included in our study.
Four ATM single nucleotide polymorphisms (SNPs) were genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS).
Association between genotypes and the gender-specific risk of metastasis was assessed by odds ratios (OR) and 95% confidence intervals (CI) under the unconditional logistic regression analysis.
Significant associations were observed between rs189037 and metastasis of PTC in females under different models of inheritance (codominant model: OR=0.15, 95% CI 0.04–0.56, P=0.01 for GA versus GG and OR=0.08, 95% CI 0.01–0.74, P=0.03 for AA versus GG, resp.; dominant model: OR=0.49, 95% CI 0.25–0.98, P=0.04; overdominant model: OR=0.47, 95% CI 0.25–0.89, P=0.02).
However, no association remained significant after Bonferroni correction.
Our findings suggest a possible association between ATM rs189037 polymorphisms and metastasis in female PTCs.
American Psychological Association (APA)
Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Ai, Lizhe& Sun, Hui…[et al.]. 2014. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036479
Modern Language Association (MLA)
Gu, Yulu…[et al.]. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036479
American Medical Association (AMA)
Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Ai, Lizhe& Sun, Hui…[et al.]. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036479