Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach
Joint Authors
Magalhaes, Jose
Monteiro, Rosário
Guimarães, J. T.
Pereira, Cidália Dionísio
Severo, Milton
Araújo, João Ricardo
Pestana, Diogo
Santos, Alejandro
Ferreira, Rita
Martins, Maria João
Ascensao, Antonio
Azevedo, Isabel
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The Metabolic Syndrome increases the risk for atherosclerotic cardiovascular disease and type 2 Diabetes Mellitus.
Increased fructose consumption and/or mineral deficiency have been associated with Metabolic Syndrome development.
This study aimed to investigate the effects of 8 weeks consumption of a hypersaline sodium-rich naturally sparkling mineral water on 10% fructose-fed Sprague-Dawley rats (Metabolic Syndrome animal model).
The ingestion of the mineral water (rich in sodium bicarbonate and with higher potassium, calcium, and magnesium content than the tap water used as control) reduced/prevented not only the fructose-induced increase of heart rate, plasma triacylglycerols, insulin and leptin levels, hepatic catalase activity, and organ weight to body weight ratios (for liver and both kidneys) but also the decrease of hepatic glutathione peroxidase activity and oxidized glutathione content.
This mineral-rich water seems to have potential to prevent Metabolic Syndrome induction by fructose.
We hypothesize that its regular intake in the context of modern diets, which have a general acidic character interfering with mineral homeostasis and are poor in micronutrients, namely potassium, calcium, and magnesium, could add surplus value and attenuate imbalances, thus contributing to metabolic and redox health and, consequently, decreasing the risk for atherosclerotic cardiovascular disease.
American Psychological Association (APA)
Pereira, Cidália Dionísio& Severo, Milton& Araújo, João Ricardo& Guimarães, J. T.& Pestana, Diogo& Santos, Alejandro…[et al.]. 2014. Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036483
Modern Language Association (MLA)
Pereira, Cidália Dionísio…[et al.]. Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach. International Journal of Endocrinology No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1036483
American Medical Association (AMA)
Pereira, Cidália Dionísio& Severo, Milton& Araújo, João Ricardo& Guimarães, J. T.& Pestana, Diogo& Santos, Alejandro…[et al.]. Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water to the Protection against Metabolic Syndrome Induction in Fructose-Fed Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036483