Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model
Joint Authors
Koh, Jang Hyun
Lee, Eun Soo
Hyun, Miri
Kim, Hong Min
Choi, Yoon Jung
Lee, Eun Young
Yadav, Dhananjay
Chung, Choon Hee
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The overexpression of vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of diabetic nephropathy.
In this study, the protective effects of taurine on diabetic nephropathy along with its underlying mechanism were investigated.
Experimental animals were divided into three groups: LETO rats as normal group ( n = 10 ), OLETF rats as diabetic control group ( n = 10 ), and OLETF rats treated with taurine group ( n = 10 ).
We treated taurine (200 mg/kg/day) for 20 weeks and treated high glucose (HG, 30 mM) with or without taurine (30 mM) in mouse cultured podocyte.
After taurine treatment, blood glucose level was decreased and insulin secretion was increased.
Taurine significantly reduced albuminuria and ACR.
Also it decreased glomerular volume, GBM thickness and increased open slit pore density through decreased VEGF and increased nephrin mRNA expressions in renal cortex.
The antioxidant effects of taurine were confirmed by the reduction of urine MDA in taurine treated diabetic group.
Also reactive oxygen species (ROS) levels were decreased in HG condition with taurine treated podocytes compared to without taurine.
These results indicate that taurine lowers glucose level via increased insulin secretion and ameliorates the progression of diabetic nephropathy through antifibrotic and antioxidant effects in type 2 diabetes rat model.
American Psychological Association (APA)
Koh, Jang Hyun& Lee, Eun Soo& Hyun, Miri& Kim, Hong Min& Choi, Yoon Jung& Lee, Eun Young…[et al.]. 2014. Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036489
Modern Language Association (MLA)
Koh, Jang Hyun…[et al.]. Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036489
American Medical Association (AMA)
Koh, Jang Hyun& Lee, Eun Soo& Hyun, Miri& Kim, Hong Min& Choi, Yoon Jung& Lee, Eun Young…[et al.]. Taurine Alleviates the Progression of Diabetic Nephropathy in Type 2 Diabetic Rat Model. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036489