Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin
Joint Authors
Tokodai, Kazuaki
Amada, Noritoshi
Haga, Izumi
Nakamura, Atsushi
Kashiwadate, Toshiaki
Kawagishi, Naoki
Ohuchi, Noriaki
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To evaluate the predictive power of pretransplant HbA1c for new-onset diabetes after transplantation (NODAT) in kidney transplant candidates, who had several predispositions for fluctuated HbA1c levels.
Methods.
We performed a retrospective study of 119 patients without diabetes who received kidney transplantation between March 2000 and January 2012.
Univariate and multivariate logistic regression analyses were used to investigate the association of several parameters with NODAT.
Predictive discrimination of HbA1c was assessed using a receiver-operating characteristic curve.
Results.
Seventeen patients (14.3%) developed NODAT within 1 year of transplantation.
Univariate logistic regression analysis revealed that recipient age, gender, and HbA1c were predictors of NODAT.
In the multivariate analysis, the association between pretransplant HbA1c and NODAT development did not reach statistical significance ( P = 0.07 ).
To avoid the strong influence of high-dose erythropoietin on HbA1c levels, we performed subgroup analyses on 85 patients receiving no or low-dose (≤6000 IU/week) erythropoietin.
HbA1c was again an independent predictor for NODAT.
Receiver-operating characteristic analysis revealed a cut-off value of 5.2% with an optimal sensitivity of 64% and specificity of 78% for predicting NODAT.
Conclusions.
Our results reveal that the pretransplant HbA1c level is a useful predictor for NODAT in patients receiving no or low-dose erythropoietin.
American Psychological Association (APA)
Tokodai, Kazuaki& Amada, Noritoshi& Haga, Izumi& Nakamura, Atsushi& Kashiwadate, Toshiaki& Kawagishi, Naoki…[et al.]. 2014. Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036495
Modern Language Association (MLA)
Tokodai, Kazuaki…[et al.]. Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036495
American Medical Association (AMA)
Tokodai, Kazuaki& Amada, Noritoshi& Haga, Izumi& Nakamura, Atsushi& Kashiwadate, Toshiaki& Kawagishi, Naoki…[et al.]. Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036495
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036495