![](/images/graphics-bg.png)
Inflammatory Response in Islet Transplantation
Joint Authors
Kanak, Mazhar A.
Takita, Morihito
Kunnathodi, Faisal
Lawrence, Michael C.
Levy, Marlon F.
Naziruddin, Bashoo
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis.
Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes.
Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation.
The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation.
Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented.
Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent.
We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment.
Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation.
American Psychological Association (APA)
Kanak, Mazhar A.& Takita, Morihito& Kunnathodi, Faisal& Lawrence, Michael C.& Levy, Marlon F.& Naziruddin, Bashoo. 2014. Inflammatory Response in Islet Transplantation. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036496
Modern Language Association (MLA)
Kanak, Mazhar A.…[et al.]. Inflammatory Response in Islet Transplantation. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036496
American Medical Association (AMA)
Kanak, Mazhar A.& Takita, Morihito& Kunnathodi, Faisal& Lawrence, Michael C.& Levy, Marlon F.& Naziruddin, Bashoo. Inflammatory Response in Islet Transplantation. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036496