Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha
Joint Authors
Simsek, Yasin
Sener, Elif Funda
Tascioglu, Nazife
Dundar, Munis
Diri, Halit
Bayram, Fahri
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sheehan’s Syndrome (SS) is defined as pituitary hormone deficiency due to ischemic infarction of the pituitary gland as a result of massive postpartum uterine hemorrhage.
Herein, we aimed to investigate the roles of Factor II (G20210A), Factor V (G1691A), MTHFR (C677T and A1298C), PAI-1 4G/5G, and TNF-α ( - 308 G > A ) gene polymorphisms in the etiopathogenesis of SS.
Venous blood samples were obtained from 53 cases with SS and 43 healthy women.
Standard methods were used to extract the genomic DNAs.
Factor II (G20210A), Factor V (G1691A), and MTHFR (C677T and A1298C) polymorphisms were identified by real-time PCR.
PAI-1 4G/5G and TNF-α ( - 308 G > A ) gene polymorphisms were detected with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods.
According to statistical analysis, none of the polymorphisms were found to be significantly higher in the SS group compared to the control group.
Hence, we suggest that genetic factors other than Factor II, Factor V, MTHFR, PAI-1, and TNF-α gene polymorphisms should be researched in the etiopathogenesis of SS.
American Psychological Association (APA)
Diri, Halit& Sener, Elif Funda& Bayram, Fahri& Tascioglu, Nazife& Simsek, Yasin& Dundar, Munis. 2014. Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036509
Modern Language Association (MLA)
Diri, Halit…[et al.]. Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036509
American Medical Association (AMA)
Diri, Halit& Sener, Elif Funda& Bayram, Fahri& Tascioglu, Nazife& Simsek, Yasin& Dundar, Munis. Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036509