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Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome
Joint Authors
Aversa, Antonio
Lenzi, Andrea
Francomano, Davide
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metabolic and hormonal modifications after long-term testosterone (T) treatment have never been investigated.
20 hypogonadal men (mean T = 241 ng/dL–8.3 nmol/L) with metabolic syndrome (MS, mean age 58) were treated with T-undecanoateinjections every 12 weeks for 60 months.
20 matched subjects in whom T was unaccepted or contraindicatedserved as controls.
Primary endpoints were variations from baseline of metabolic and hormonal parameters.
In T-group, significant reductions in waist circumference ( − 9.6 ± 3.8 cm, P < 0.0001 ), body weight ( − 15 ± 2.8 Kg, P < 0.0001 ), and glycosylated hemoglobin ( − 1.6 ± 0.5 %, P < 0.0001 ) occurred, along with improvements in insulin sensitivity (HOMA-I; − 2.8 ± 0.6 , P < 0.0001 ), lipid profile (total/HDL-cholesterol ratio − 2.9 ± 1.5 , P < 0.0001 ), systolic and diastolic blood pressure ( − 23 ± 10 and − 16 ± 8 mm Hg, P < 0.0001 , resp.), and neck and lumbar T-scores ( + 0.5 ± 0.15 gr/cm2, P < 0.0001 ; + 0.7 ± 0.8 , P < 0.0001 , resp.).
Also, serum vitamin D ( + 14.0 ± 1.3 ng/mL, P < 0.01 ), TSH ( − 0.9 ± 0.3 mUI/mL, P < 0.01 ), GH ( 0.74 ± 0.2 ng/mL, P < 0.0001 ), and IGF1 ( 105 ± 11 ng/mL, P < 0.01 ) levels changed in T-group but not in controls.
Normalization of T levels in men with MS improved obesity, glycemic control, blood pressure, lipid profile, and bone mineral density compared with controls.
Amelioration in hormonal parameters, that is, vitamin D, growth hormone, and thyrotropin plasma levels, were reported.
American Psychological Association (APA)
Francomano, Davide& Lenzi, Andrea& Aversa, Antonio. 2013. Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036513
Modern Language Association (MLA)
Francomano, Davide…[et al.]. Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036513
American Medical Association (AMA)
Francomano, Davide& Lenzi, Andrea& Aversa, Antonio. Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome. International Journal of Endocrinology. 2013. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036513