Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients
Joint Authors
Watada, Hirotaka
Uchida, Toyoyoshi
Takagi, Atsutoshi
Sekita, Gaku
Komiya, Koji
Takeno, Kageumi
Shigihara, Nayumi
Shimada, Kazunori
Miyauchi, Katsumi
Fujitani, Yoshio
Kasai, T.
Daida, Hiroyuki
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Amiodarone is a widely used agent for life-threatening arrhythmias.
Although amiodarone-induced thyrotoxicosis (AIT) is a major adverse effect that can cause recurrence of arrhythmias and exacerbation of heart failure, risk factors for AIT among amiodarone-treated Japanese patients have not been elucidated.
Here, we investigated the prevalence and predictive factors for AIT.
The study subjects were 225 patients treated with amiodarone between 2008 and 2012, who were euthyroid before amiodarone therapy.
All patients with AIT were diagnosed by measurement of thyroid hormones and ultrasonography.
Among the 225 subjects, 13 patients (5.8%) developed AIT and all the patients were classified as Type 2 AIT.
Baseline features of patients with AIT were not different from those who did not develop AIT, except for age (AIT, 55.1 ± 13.8, non-AIT, 68.1 ± 12.0 years, P < 0.001 ).
Multivariate analyses using the Cox proportional hazard model identified age as the sole determinant of AIT (hazard ratio: 0.927, 95% confidence interval: 0.891–0.964).
Receiver operating characteristic curve analysis identified age of 63.5 years as the cutoff value for AIT with sensitivity of 70.3% and specificity of 69.2%.
In summary, this study showed that the prevalence of AIT is 5.8% in Japanese patients treated with amiodarone and that young age is a risk factor for AIT.
American Psychological Association (APA)
Uchida, Toyoyoshi& Kasai, T.& Takagi, Atsutoshi& Sekita, Gaku& Komiya, Koji& Takeno, Kageumi…[et al.]. 2014. Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036516
Modern Language Association (MLA)
Uchida, Toyoyoshi…[et al.]. Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036516
American Medical Association (AMA)
Uchida, Toyoyoshi& Kasai, T.& Takagi, Atsutoshi& Sekita, Gaku& Komiya, Koji& Takeno, Kageumi…[et al.]. Prevalence of Amiodarone-Induced Thyrotoxicosis and Associated Risk Factors in Japanese Patients. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036516