FBP1 Is an Interacting Partner of Menin
Joint Authors
Zaman, Shadia
Sukhodolets, Karen
Wang, Patricia
Qin, Jun
Levens, David
Agarwal, Sunita K.
Marx, Stephen J.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by tumors in multiple endocrine tissues such as the parathyroid glands, the pituitary gland, and the enteropancreatic neuroendocrine tissues.
MEN1 is usually caused by mutations in the MEN1 gene that codes for the protein menin.
Menin interacts with proteins that regulate transcription, DNA repair and processing, and maintenance of cytoskeletal structure.
We describe the identification of FBP1 as an interacting partner of menin in a large-scale pull-down assay that also immunoprecipitated RBBP5, ASH2, and LEDGF, which are members of complex proteins associated with SET1 (COMPASS), a protein complex that methylates histone H3.
This interaction was confirmed by coimmunoprecipitation and Flag-pull-down assays.
Furthermore, menin localized to the FUSE site on the MYC promoter, a site that is transactivated by FBP1.
This investigation therefore places menin in a pathway that regulates MYC gene expression and has important implications for the biological function of menin.
American Psychological Association (APA)
Zaman, Shadia& Sukhodolets, Karen& Wang, Patricia& Qin, Jun& Levens, David& Agarwal, Sunita K.…[et al.]. 2014. FBP1 Is an Interacting Partner of Menin. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036517
Modern Language Association (MLA)
Zaman, Shadia…[et al.]. FBP1 Is an Interacting Partner of Menin. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036517
American Medical Association (AMA)
Zaman, Shadia& Sukhodolets, Karen& Wang, Patricia& Qin, Jun& Levens, David& Agarwal, Sunita K.…[et al.]. FBP1 Is an Interacting Partner of Menin. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036517