Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta
Joint Authors
Pazos, Patricia
Lima, Luis
García, María C.
Dieguez, Carlos
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The placenta produces a number of signaling molecules including metabolic and reproductive hormones as well as several inflammatory mediators.
Among them, Interleukin-6 (IL-6), a well-known immune and metabolic regulator, acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat.
IL-6 interacts with key hypothalamic neuropeptidergic systems controlling energy homeostasis such as those producing the orexigenic/anabolic: neuropeptide Y (NPY) and agouti-related peptide (AgRP) and anorectic/catabolic neuropeptides: proopiomelanocortin (POMC) and cocaine and amphetamine regulated transcript (CART).
Human and rat placenta have been identified as source of these neuropeptides, but their expression and regulation in murine placental tissues remain unknown.
Therefore, placental mRNA levels of IL-6, NPY, AgRP, POMC, and CART at different pregnancy stages (gestational days 13, 15, and 18) were analyzed by real time PCR, as were the effect of IL-6 deficiency (IL-6 knockout mice) on their placental expression.
Our results showed that placenta-derived neuropeptides were regulated by gestational age and IL-6 throughout the second half of mouse pregnancy.
These data suggest that IL-6 may participate in the fine tune control of energy balance during pregnancy by extending its action as a metabolic signal to the main organ at the fetomaternal interface: the placenta.
American Psychological Association (APA)
Pazos, Patricia& Lima, Luis& Dieguez, Carlos& García, María C.. 2014. Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036518
Modern Language Association (MLA)
Pazos, Patricia…[et al.]. Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta. International Journal of Endocrinology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036518
American Medical Association (AMA)
Pazos, Patricia& Lima, Luis& Dieguez, Carlos& García, María C.. Energy Balance Regulating Neuropeptides Are Expressed through Pregnancy and Regulated by Interleukin-6 Deficiency in Mouse Placenta. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036518