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Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men
Joint Authors
Huang, Wu
Zhan, Jun-Kun
Wang, Yi
Tang, Zhi-Yong
Tan, Pan
Gao, Shan
Ma, Cai-Li
Jian, Zai-Jin
Liu, You-Shuo
Wang, Yan-Jiao
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Vitamin D binding protein (DBP) may alter the biologic activity of 25-hydroxyvitamin D [25(OH)D].
The objective of our present study was to determine the joint effect of serum 25(OH)D and DBP on the risk of frailty.
Five hundred sixteen male participants aged 70 years or older were recruited in Changsha city and its surrounding area in Hunan province of China.
Frailty was defined as the presence of at least three of the five following criteria: weakness, low physical activity, slow walking speed, exhaustion, and weight loss.
Multivariate linear regression analysis was performed to assess the relationship between 25(OH)D and DBP levels.
Odds ratios (ORs) for frailty were evaluated across quartiles of 25(OH)D and DBP levels, adjusted age, education, and body mass index.
The results showed that participants in the lowest quartile of 25(OH)D and the highest quartile of DBP levels, the lowest quartile of 25(OH)D and the lowest quartile of DBP levels, and those in the the lower quartile of 25(OH)D and lowest quartile of DBP levels had significantly higher OR of being frail compared with those in the highest quartile of 25(OH)D and lowest quartile of DBP, with OR of 3.18 (95% CI: 1.46–4.56, P < 0.05 ), 2.63 (95% CI: 1.31–3.68, P < 0.01 ), and 2.52 (95% CI: 1.22–3.52, P < 0.05 ), respectively.
The results indicate that the joint effect of serum 25(OH)D and DBP levels is associated with the risk of frailty, and serum DBP levels affects 25(OH)D-frailty relationship in the older men.
American Psychological Association (APA)
Wang, Yi& Wang, Yan-Jiao& Zhan, Jun-Kun& Tang, Zhi-Yong& Huang, Wu& Tan, Pan…[et al.]. 2014. Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036519
Modern Language Association (MLA)
Wang, Yi…[et al.]. Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036519
American Medical Association (AMA)
Wang, Yi& Wang, Yan-Jiao& Zhan, Jun-Kun& Tang, Zhi-Yong& Huang, Wu& Tan, Pan…[et al.]. Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036519