![](/images/graphics-bg.png)
Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease
Joint Authors
Verrua, Elisa
Ferrante, Emanuele
Filopanti, Marcello
Malchiodi, Elena
Sala, Elisa
Giavoli, Claudia
Arosio, Maura
Lania, Andrea Gerardo
Ronchi, Cristina Lucia
Mantovani, Giovanna
Spada, Anna
Beck-Peccoz, Paolo
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management.
This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, and comorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria.
At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 μg/L in 11 patients (Group A) and below 0.4 μg/L in 29 patients (Group B); moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only.
No differences in other evaluated parameters were found.
These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be too low for the currently used GH assay.
American Psychological Association (APA)
Verrua, Elisa& Ferrante, Emanuele& Filopanti, Marcello& Malchiodi, Elena& Sala, Elisa& Giavoli, Claudia…[et al.]. 2014. Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036525
Modern Language Association (MLA)
Verrua, Elisa…[et al.]. Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036525
American Medical Association (AMA)
Verrua, Elisa& Ferrante, Emanuele& Filopanti, Marcello& Malchiodi, Elena& Sala, Elisa& Giavoli, Claudia…[et al.]. Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036525