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High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response
Joint Authors
Civcic, Milorad
Aleksic, Sandra
Milicic, Tanja
Markovic, Ivanka
Jeremic, Veljko
Rajkovic, Natasa
Popadic, Dušan
Stanarcic, Jelena
Lalic, Katarina
Macesic, Marija
Jotic, Aleksandra
Lalic, Nebojsa M.
Seferovic, Jelena P.
Lukic, Ljiljana
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We analyzed the level of (a) CXCR3+ (Th1) and CCR4+ (Th2) T memory cells (b) interferon-γ inducible chemokine (IP-10)(Th1) and thymus and activation-regulated chemokine (TARC)(Th2), in 51 first degree relatives (FDRs) of type 1 diabetics (T1D) (17 high risk FDRs (GADA+, IA-2+) and 34 low risk FDRs (GADA−, IA-2−)), 24 recent-onset T1D (R-T1D), and 18 healthy subjects.
T memory subsets were analyzed by using four-color immunofluorescence staining and flowcytometry.
IP-10 and TARC were determined by ELISA.
High risk FDRs showed higher levels of CXCR3+ and lower level of CCR4+ T memory cells compared to low risk FDRs (64.98 ± 5.19 versus 42.13 ± 11.11; 29.46 ± 2.83 versus 41.90 ± 8.58%, resp., P < 0.001 ).
Simultaneously, both IP-10 and TARC levels were increased in high risk versus low risk FDRs (160.12 ± 73.40 versus 105.39 ± 71.30; 438.83 ± 120.62 versus 312.04 ± 151.14 pg/mL, P < 0.05 ).
Binary logistic regression analysis identified the level of CXCR3+ T memory cells as predictors for high risk FDRs, together with high levels of IP-10.
The results imply that, in FDRs, the risk for T1D might be strongly influenced by enhanced activity of Th1 and diminished activity of Th2 autoimmune response.
American Psychological Association (APA)
Milicic, Tanja& Jotic, Aleksandra& Markovic, Ivanka& Lalic, Katarina& Jeremic, Veljko& Lukic, Ljiljana…[et al.]. 2014. High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036528
Modern Language Association (MLA)
Milicic, Tanja…[et al.]. High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036528
American Medical Association (AMA)
Milicic, Tanja& Jotic, Aleksandra& Markovic, Ivanka& Lalic, Katarina& Jeremic, Veljko& Lukic, Ljiljana…[et al.]. High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036528