MicroRNAs in Diabetic Kidney Disease
Joint Authors
Li, Rong
Chung, Arthur C. K.
Yu, Xueqing
Lan, Hui Y.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society.
Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation.
It is urgent to search for biomarkers for early diagnosis and effective therapy.
The discovery of microRNAs had lead to a new era of post-transcriptional regulators of gene expression.
Studies from cells, experimental animal models and patients under diabetic conditions demonstrate that expression patterns of microRNAs are altered during the progression of diabetic kidney disease.
Functional studies indicate that the ability of microRNAs to bind 3′ untranslated region of messenger RNA not only shows their capability to regulate expression of target genes, but also their therapeutic potential to diabetic kidney disease.
The presence of microRNAs in plasma, serum, and urine has been shown to be possible biomarkers in diabetic kidney disease.
Therefore, identification of the pathogenic role of microRNAs possesses an important clinical impact in terms of prevention and treatment of progression in diabetic kidney disease because it allows us to design novel and specific therapies and diagnostic tools for diabetic kidney disease.
American Psychological Association (APA)
Li, Rong& Chung, Arthur C. K.& Yu, Xueqing& Lan, Hui Y.. 2014. MicroRNAs in Diabetic Kidney Disease. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036531
Modern Language Association (MLA)
Li, Rong…[et al.]. MicroRNAs in Diabetic Kidney Disease. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036531
American Medical Association (AMA)
Li, Rong& Chung, Arthur C. K.& Yu, Xueqing& Lan, Hui Y.. MicroRNAs in Diabetic Kidney Disease. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036531