Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes
Joint Authors
Giandalia, Annalisa
Alibrandi, Angela
Horvath, Katalin V.
Asztalos, Bela F.
Russo, Giuseppina T.
Cucinotta, Domenico
Romeo, Elisabetta L.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Besides their role in reverse cholesterol transport, HDL particles may affect the atherosclerotic process through the modulation of subclinical inflammation.
HDL particles differ in size, composition, and, probably, anti-inflammatory properties.
This hypothesis has never been explored in diabetic women, frequently having dysfunctional HDL.
The potential relationship between lipid profile, Apo-AI containing HDL subclasses distribution, and common inflammatory markers (hsCRP, IL-6) was examined in 160 coronary heart disease- (CHD-) free women with and without type 2 diabetes.
Results.
Compared to controls, diabetic women showed lower levels of the atheroprotective large α-1, α-2, and pre-α-1 and higher concentration of the small, lipid-poor α-3 HDL particles ( P < 0.05 all); diabetic women also had higher hsCRP and IL-6 serum levels (age- and BMI-adjusted P < 0.001 ).
Overall, HDL subclasses significantly correlated with inflammatory markers: hsCRP inversely correlated with α-1 ( P = 0.01 ) and pre-α-1 ( P = 0.003 ) ; IL-6 inversely correlated with α-1 ( P = 0.003 ) , α-2 ( P = 0.004 ) , and pre-α-1 ( P = 0.002 ) and positively with α-3 HDL ( P = 0.03 ) .
Similar correlations were confirmed at univariate regression analysis.
Conclusions.
More atheroprotective HDL subclasses are associated with lower levels of inflammatory markers, especially in diabetic women.
These data suggest that different HDL subclasses may influence CHD risk also through the modulation of inflammation.
American Psychological Association (APA)
Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Alibrandi, Angela& Horvath, Katalin V.& Asztalos, Bela F.…[et al.]. 2014. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036534
Modern Language Association (MLA)
Russo, Giuseppina T.…[et al.]. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036534
American Medical Association (AMA)
Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Alibrandi, Angela& Horvath, Katalin V.& Asztalos, Bela F.…[et al.]. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036534