Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes

Joint Authors

Giandalia, Annalisa
Alibrandi, Angela
Horvath, Katalin V.
Asztalos, Bela F.
Russo, Giuseppina T.
Cucinotta, Domenico
Romeo, Elisabetta L.

Source

International Journal of Endocrinology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-09-02

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Background.

Besides their role in reverse cholesterol transport, HDL particles may affect the atherosclerotic process through the modulation of subclinical inflammation.

HDL particles differ in size, composition, and, probably, anti-inflammatory properties.

This hypothesis has never been explored in diabetic women, frequently having dysfunctional HDL.

The potential relationship between lipid profile, Apo-AI containing HDL subclasses distribution, and common inflammatory markers (hsCRP, IL-6) was examined in 160 coronary heart disease- (CHD-) free women with and without type 2 diabetes.

Results.

Compared to controls, diabetic women showed lower levels of the atheroprotective large α-1, α-2, and pre-α-1 and higher concentration of the small, lipid-poor α-3 HDL particles ( P < 0.05 all); diabetic women also had higher hsCRP and IL-6 serum levels (age- and BMI-adjusted P < 0.001 ).

Overall, HDL subclasses significantly correlated with inflammatory markers: hsCRP inversely correlated with α-1 ( P = 0.01 ) and pre-α-1 ( P = 0.003 ) ; IL-6 inversely correlated with α-1 ( P = 0.003 ) , α-2 ( P = 0.004 ) , and pre-α-1 ( P = 0.002 ) and positively with α-3 HDL ( P = 0.03 ) .

Similar correlations were confirmed at univariate regression analysis.

Conclusions.

More atheroprotective HDL subclasses are associated with lower levels of inflammatory markers, especially in diabetic women.

These data suggest that different HDL subclasses may influence CHD risk also through the modulation of inflammation.

American Psychological Association (APA)

Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Alibrandi, Angela& Horvath, Katalin V.& Asztalos, Bela F.…[et al.]. 2014. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036534

Modern Language Association (MLA)

Russo, Giuseppina T.…[et al.]. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036534

American Medical Association (AMA)

Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Alibrandi, Angela& Horvath, Katalin V.& Asztalos, Bela F.…[et al.]. Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036534

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1036534