Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity
Joint Authors
Młynarski, Wojciech
Fendler, Wojciech
Ramatowska, Anna
Szypowska, Agnieszka
Szadkowska, Agnieszka
Chumiecki, Miron
Chrzanowska, Joanna
Noczyńska, Anna
Brandt, Agnieszka
Myśliwiec, Małgorzata
Bernatowicz, Paweł
Kowalczuk, Oksana
Jarosz-Chobot, Przemyslawa
Bossowski, Artur
Łuczyński, Włodzimierz
Głowińska-Olszewska, Barbara
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity.
A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study.
All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36.
Results.
Variants of FTO showed significant association with BMI-SDS in the T1DM group.
The main factors influencing BMI-SDS in children with T1DM included female gender ( P = 0.0003 ), poor metabolic control ( P = 0.0001 ), and carriage of the A allele of the FTO rs9939609 gene ( P = 0.02 ).
Conclusion.
Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control.
This trial is registered with ClinicalTrials.gov (NCT01279161).
American Psychological Association (APA)
Łuczyński, Włodzimierz& Fendler, Wojciech& Ramatowska, Anna& Szypowska, Agnieszka& Szadkowska, Agnieszka& Młynarski, Wojciech…[et al.]. 2014. Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036544
Modern Language Association (MLA)
Łuczyński, Włodzimierz…[et al.]. Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity. International Journal of Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036544
American Medical Association (AMA)
Łuczyński, Włodzimierz& Fendler, Wojciech& Ramatowska, Anna& Szypowska, Agnieszka& Szadkowska, Agnieszka& Młynarski, Wojciech…[et al.]. Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036544
