Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease
Joint Authors
Marino, Marco
Moriondo, Valeria
Vighi, Eleonora
Pignatti, Elisa
Simoni, Manuela
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Central hypogonadotropic hypogonadism (CHH) is an emerging pathological condition frequently associated with overweight, metabolic syndrome, diabetes, and midline defects.
The genetic mechanisms involve mutations in at least twenty-four genes regulating GnRH neuronal migration, secretion, and activity.
So far, the mechanisms underlying CHH, both in prepubertal and in adulthood onset forms, remain unknown in most of the cases.
Indeed, all detected gene variants may explain a small proportion of the affected patients (43%), indicating that other genes or epigenetic mechanisms are involved in the onset of CHH.
The aim of this review is to summarize the current knowledge on genetic background of CHH, organizing the large amount of data present in the literature in a clear and concise manner, to produce a useful guide available for researchers and clinicians.
American Psychological Association (APA)
Marino, Marco& Moriondo, Valeria& Vighi, Eleonora& Pignatti, Elisa& Simoni, Manuela. 2014. Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036548
Modern Language Association (MLA)
Marino, Marco…[et al.]. Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036548
American Medical Association (AMA)
Marino, Marco& Moriondo, Valeria& Vighi, Eleonora& Pignatti, Elisa& Simoni, Manuela. Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036548