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Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial
Joint Authors
Bitto, Alessandra
Corrado, F.
D’Anna, Rosario
Santamaria, Angelo
Cannata, Maria Letizia
Interdonato, Maria Lieta
Giorgianni, Grazia Maria
Granese, Roberta
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
Cardiovascular risk is increased in women with menopause and metabolic syndrome.
Aim of this study was to test the effect of a new supplement formula, combining cocoa polyphenols, myo-inositol, and soy isoflavones, on some biomarkers of cardiovascular risk in postmenopausal women with metabolic syndrome.
Methods and Results.
A total of 60 women were enrolled and randomly assigned (n=30 per group) to receive the supplement (NRT: 30 mg of cocoa polyphenols, 80 mg of soy isoflavones, and 2 gr of myo-inositol), or placebo for 6 months.
The study protocol included three visits (baseline, 6, and 12 months) for the evaluation of glucose, triglycerides, and HDL-cholesterol (HDL-C), adiponectin, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP).
At 6 months, a significant difference between NRT and placebo was found for glucose (96±7 versus 108±10 mg/dL), triglycerides (145±14 versus 165±18 mg/dL), visfatin (2.8±0.8 versus 3.7±1.1 ng/mL), resistin (27±7 versus 32±8 µg/L), and b-ALP (19±7 versus 15±5 µg/mL).
No difference in HDL-C concentrations nor in adiponectin levels between groups was reported at 6 months.
Conclusions.
The supplement used in this study improves most of the biomarkers linked to metabolic syndrome.
This Trial is registered with NCT01400724.
American Psychological Association (APA)
D’Anna, Rosario& Santamaria, Angelo& Cannata, Maria Letizia& Interdonato, Maria Lieta& Giorgianni, Grazia Maria& Granese, Roberta…[et al.]. 2014. Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036550
Modern Language Association (MLA)
D’Anna, Rosario…[et al.]. Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036550
American Medical Association (AMA)
D’Anna, Rosario& Santamaria, Angelo& Cannata, Maria Letizia& Interdonato, Maria Lieta& Giorgianni, Grazia Maria& Granese, Roberta…[et al.]. Effects of a New Flavonoid and Myo-Inositol Supplement on Some Biomarkers of Cardiovascular Risk in Postmenopausal Women: A Randomized Trial. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036550