Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
Joint Authors
Lee, Chien-Hsing
Hsiao, Fone-Ching
Chu, Nain-Feng
Hsieh, Po-Shiuan
Shieh, Yi-Shing
Hsieh, Chang-Hsun
Lee, Ting-I
Lin, Yuh-Feng
Hung, Yi-Jen
Chen, Yii-der Ida
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents.
After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years.
We genotyped the adolescents’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms.
Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers.
There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113.
Boys with both the GG genotype of GAS6 rs8191973 and the GG genotype of GAS6 rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the GAS6 rs8191973 and the A allele of the GAS6 rs8191974.
In conclusion, GAS6 and AXL polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.
American Psychological Association (APA)
Hsiao, Fone-Ching& Lin, Yuh-Feng& Hsieh, Po-Shiuan& Chu, Nain-Feng& Chen, Yii-der Ida& Shieh, Yi-Shing…[et al.]. 2014. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036556
Modern Language Association (MLA)
Hsiao, Fone-Ching…[et al.]. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036556
American Medical Association (AMA)
Hsiao, Fone-Ching& Lin, Yuh-Feng& Hsieh, Po-Shiuan& Chu, Nain-Feng& Chen, Yii-der Ida& Shieh, Yi-Shing…[et al.]. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036556