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Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1CD71
Joint Authors
Parenti, Rosalba
Salvatorelli, Lucia
Magro, Gaetano
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers.
Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine (131I) therapy.
Accordingly, genetic and molecular characterizations of ATC have been frequently and periodically reviewed in order to identify potential biological markers exploitable for target therapy.
This review briefly focuses on main molecular events that characterize ATC and provides an update about preclinical studies.
In addition, the overexpression of transferrin receptor 1 (TfR1/CD71) by neoplastic cells of ATC is emphasized in that it could represent a potential therapeutic target.
In this regard, new therapeutic approaches based on the use of monoclonal or recombinant antibodies, or transferrin-gallium-TfR1/CD71 molecular complexes, or lastly small interfering RNAs (siRNAs) are proposed.
American Psychological Association (APA)
Parenti, Rosalba& Salvatorelli, Lucia& Magro, Gaetano. 2014. Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1CD71. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036560
Modern Language Association (MLA)
Parenti, Rosalba…[et al.]. Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1CD71. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036560
American Medical Association (AMA)
Parenti, Rosalba& Salvatorelli, Lucia& Magro, Gaetano. Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1CD71. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036560