Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis
Joint Authors
Milewski, Robert
Popławska-Kita, Anna
Szelachowska, Małgorzata
Telejko, Beata
Kościuszko-Zdrodowska, Maria
Wawrusewicz-Kurylonek, Natalia
Krętowski, Adam
Hryniewicka, Justyna
Dzięcioł, Janusz
Bauer, Witold
Górska, Maria
Siewko, Katarzyna
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals.
Subjects and Methods.
Thyroid cells were obtained from 39 patients with HT and 15 controls by an ultrasound guided fine needle aspiration biopsy.
Results.
The patients with HT had lower Tg and NIS mRNA ( P = 0.002 and P = 0.001 , resp.), as well as higher TNFα mRNA expression ( P = 0.049 ) than the controls.
In the HT group Tg mRNA expression correlated positively with NIS mRNA expression ( R = 0.739 , P = 0.0001 ) and thyroid volume ( R = 0.465 , P = 0.0005 ), as well as negatively with TNFα mRNA expression ( R = - 0.490 , P = 0.001 ) and anti-peroxidase antibodies (TPOAb) level ( R = - 0.482 , P = 0.0002 ), whereas NIS mRNA expression correlated positively with thyroid volume ( R = 0.319 , P = 0.02 ), as well as negatively with TNFα mRNA expression ( R = - 0.529 , P = 0.0006 ) and TPOAb level ( R = - 0.422 , P = 0.001 ).
Conclusions.
Our results suggest that decreased Tg and NIS expression in thyroid cells may result in reduced active iodide transport and reduced thyroid volume in patients with HT.
American Psychological Association (APA)
Telejko, Beata& Siewko, Katarzyna& Kościuszko-Zdrodowska, Maria& Wawrusewicz-Kurylonek, Natalia& Krętowski, Adam& Hryniewicka, Justyna…[et al.]. 2014. Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036562
Modern Language Association (MLA)
Telejko, Beata…[et al.]. Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis. International Journal of Endocrinology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036562
American Medical Association (AMA)
Telejko, Beata& Siewko, Katarzyna& Kościuszko-Zdrodowska, Maria& Wawrusewicz-Kurylonek, Natalia& Krętowski, Adam& Hryniewicka, Justyna…[et al.]. Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036562