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Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus
Joint Authors
Tomita, Masuomi
Oh, Henpiru
Ainai, Akira
Meguro, Shu
Hasegawa, Hideki
Itoh, Hiroshi
Ito, Ryo
Kato, Kiyoe
Katsuki, Takeshi
Kawai, Toshihide
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Relation between atherosclerosis and innate immunity has attracted attention.
As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus.
Materials and Methods.
We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%).
Plasma level of LL-37 was measured by ELISA.
Results.
Mean plasma LL-37 level was 71.2±22.3 ng/mL.
Plasma LL-37 level showed significant correlations with HDL cholesterol (r=−0.450, P<0.01), triglyceride (r=0.445, P<0.01), and high sensitive C-reactive protein (r=0.316, P<0.01) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein.
Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=−0.411, P<0.01) and high sensitive C-reactive protein (β=0.193, P<0.05).
Conclusion.
Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.
American Psychological Association (APA)
Meguro, Shu& Tomita, Masuomi& Katsuki, Takeshi& Kato, Kiyoe& Oh, Henpiru& Ainai, Akira…[et al.]. 2014. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036566
Modern Language Association (MLA)
Meguro, Shu…[et al.]. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036566
American Medical Association (AMA)
Meguro, Shu& Tomita, Masuomi& Katsuki, Takeshi& Kato, Kiyoe& Oh, Henpiru& Ainai, Akira…[et al.]. Plasma Antimicrobial Peptide LL-37 Level Is Inversely Associated with HDL Cholesterol Level in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036566