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Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome
Joint Authors
Xueyao, Yin
Saifei, Zhang
Dan, Yu
Qianqian, Pan
Xuehong, Dong
Jiaqiang, Zhou
Fenping, Zheng
Hong, Li
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The fractalkine/CX3CR1 axis plays an important role in regulating glucose and lipid metabolism.
However, the role of fractalkine in metabolic disorders remains to be fully elucidated.
We selected 887 Chinese (40–65 years old) at baseline, with a subgroup of 459 participants examined again 2 years later.
The relationship of serum fractalkine levels with the metabolic syndrome (MetS) and its components was investigated.
At baseline, participants with MetS had higher fractalkine concentrations than their counterparts without MetS ( P < 0.001 ).
At the 2-year follow-up, participants in the highest quartile of baseline fractalkine exhibited higher values for body mass index, waist circumference, waist-to-hip ratio, body fat percentage, glucose, insulin, total cholesterol, triglycerides (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) and lower value for high density lipoprotein-cholesterol (HDL-c) (all P < 0.05 ).
Among 390 participants without MetS at baseline, 45 developed it at year 2.
Even after multiple adjustments for visceral adipose tissue area, HOMA-IR, C-reactive protein (CRP), or TG and HDL-c, baseline fractalkine predicted the development of MetS (OR = 7.18, 95%CI: 2.28–18.59).
In conclusion, circulating fractalkine predicts the development of the MetS independently of central obesity, CRP, insulin resistance, and dyslipidemia.
American Psychological Association (APA)
Xueyao, Yin& Saifei, Zhang& Dan, Yu& Qianqian, Pan& Xuehong, Dong& Jiaqiang, Zhou…[et al.]. 2014. Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036567
Modern Language Association (MLA)
Xueyao, Yin…[et al.]. Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036567
American Medical Association (AMA)
Xueyao, Yin& Saifei, Zhang& Dan, Yu& Qianqian, Pan& Xuehong, Dong& Jiaqiang, Zhou…[et al.]. Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036567