Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes
Joint Authors
Dang, Ningning
Ding, Lin
Pang, Shuguang
Sun, Yongmei
Tian, Yuling
Yu, Li
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Type 2 diabetes (T2D) is the most prevalent metabolic disease, and many people are suffering from its complications driven by hyperglycaemia and dyslipidaemia.
Nuclear receptors (NRs) are ligand-inducible transcription factors that mediate changes to metabolic pathways within the body.
As metabolic regulators, the farnesoid X receptor (FXR) and the liver X receptor (LXR) play key roles in the pathogenesis of T2D, which remains to be clarified in detail.
Here we review the recent progress concerning the physiological and pathophysiological roles of FXRs and LXRs in the regulation of bile acid, lipid and glucose metabolism and the implications in T2D, taking into account that these two nuclear receptors are potential pharmaceutical targets for the treatment of T2D and its complications.
American Psychological Association (APA)
Ding, Lin& Pang, Shuguang& Sun, Yongmei& Tian, Yuling& Yu, Li& Dang, Ningning. 2014. Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036579
Modern Language Association (MLA)
Ding, Lin…[et al.]. Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036579
American Medical Association (AMA)
Ding, Lin& Pang, Shuguang& Sun, Yongmei& Tian, Yuling& Yu, Li& Dang, Ningning. Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036579