Bone Mineral Density in Children and Adolescents with Congenital Adrenal Hyperplasia
Joint Authors
Garcia Alves Junior, Paulo Alonso
Schueftan, Daniel Luis Gilban
de Mendonça, Laura Maria Carvalho
Beserra, Izabel Calland Ricarte
de Farias, Maria Lucia Fleiuss
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic glucocorticoid therapy is associated with reduced bone mineral density.
In paediatric patients with congenital adrenal hyperplasia, increased levels of androgens could not only counteract this effect, but could also advance bone age, with interference in the evaluation of densitometry.
We evaluate bone mineral density in paediatric patients with classic congenital adrenal hyperplasia taking into account chronological and bone ages at the time of the measurement.
Patients aged between 5 and 19 years underwent radiography of the hand and wrist followed by total body and lumbar spine densitometry.
Chronological and bone ages were used in the scans interpretation.
In fourteen patients, mean bone mineral density Z-score of total body to bone age was −0.76 and of lumbar spine to bone age was −0.26, lower than those related to chronological age (+0.03 and +0.62, resp.).
Mean Z-score differences were statistically significant ( P = 0.004 for total body and P = 0.003 for lumbar spine).
One patient was classified as having low bone mineral density only when assessed by bone age.
We conclude that there was a reduction in the bone mineral density Z-score in classic congenital adrenal hyperplasia paediatric patients when bone age was taken into account instead of chronological age.
American Psychological Association (APA)
Garcia Alves Junior, Paulo Alonso& Schueftan, Daniel Luis Gilban& de Mendonça, Laura Maria Carvalho& de Farias, Maria Lucia Fleiuss& Beserra, Izabel Calland Ricarte. 2014. Bone Mineral Density in Children and Adolescents with Congenital Adrenal Hyperplasia. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036595
Modern Language Association (MLA)
Garcia Alves Junior, Paulo Alonso…[et al.]. Bone Mineral Density in Children and Adolescents with Congenital Adrenal Hyperplasia. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036595
American Medical Association (AMA)
Garcia Alves Junior, Paulo Alonso& Schueftan, Daniel Luis Gilban& de Mendonça, Laura Maria Carvalho& de Farias, Maria Lucia Fleiuss& Beserra, Izabel Calland Ricarte. Bone Mineral Density in Children and Adolescents with Congenital Adrenal Hyperplasia. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036595