A New Aurora in Anaplastic Thyroid Cancer Therapy
Joint Authors
Ulisse, S.
Baldini, Enke
D’Armiento, Massimino
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Anaplastic thyroid cancers (ATC) are among the most aggressive human neoplasms with a dire prognosis and a median survival time of few months from the diagnosis.
The complete absence of effective therapies for ATC renders the identification of novel therapeutic approaches sorely needed.
Chromosomal instability, a feature of all human cancers, is thought to represent a major driving force in thyroid cancer progression and a number of mitotic kinases showing a deregulated expression in malignant thyroid tissues are now held responsible for thyroid tumor aneuploidy.
These include the three members of the Aurora family (Aurora-A, Aurora-B, and Aurora-C), serine/threonine kinases that regulate multiple aspects of chromosome segregation and cytokinesis.
Over the last few years, several small molecule inhibitors targeting Aurora kinases were developed, which showed promising antitumor effects against a variety of human cancers, including ATC, in preclinical studies.
Several of these molecules are now being evaluated in phase I/II clinical trials against advanced solid and hematological malignancies.
In the present review we will describe the structure, expression, and mitotic functions of the Aurora kinases, their implications in human cancer progression, with particular regard to ATC, and the effects of their functional inhibition on malignant cell proliferation.
American Psychological Association (APA)
Baldini, Enke& D’Armiento, Massimino& Ulisse, S.. 2014. A New Aurora in Anaplastic Thyroid Cancer Therapy. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036597
Modern Language Association (MLA)
Baldini, Enke…[et al.]. A New Aurora in Anaplastic Thyroid Cancer Therapy. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036597
American Medical Association (AMA)
Baldini, Enke& D’Armiento, Massimino& Ulisse, S.. A New Aurora in Anaplastic Thyroid Cancer Therapy. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036597