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Bone and Mineral Metabolism in Patients with Primary Aldosteronism
Joint Authors
Giorgio, De Toma
Zinnamosca, Laura
Settevendemmie, Amina
Nardi, Matteo
Concistrè, Antonio
Corpaci, Francesco
Tonnarini, Gianfranco
Claudio, Letizia
Petramala, Luigi
Cristiano, Marinelli
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary aldosteronism represents major cause of secondary hypertension, strongly associated with high cardiovascular morbidity and mortality.
Aldosterone excess may influence mineral homeostasis, through higher urinary calcium excretion inducing secondary increase of parathyroid hormone.
Recently, in a cohort of PA patients a significant increase of primaryhyperparathyroidism was found, suggesting a bidirectional functional link between the adrenal and parathyroid glands.
The aim of this study was to evaluate the impact of aldosterone excess on mineral metabolism and bone mass density.
In 73 PA patients we evaluated anthropometric and biochemical parameters, renin-angiotensin-aldosterone system, calcium-phosphorus metabolism, and bone mineral density; control groups were 73 essential hypertension (EH) subjects and 40 healthy subjects.
Compared to HS and EH, PA subjects had significantly lower serum calcium levels and higher urinary calcium excretion.
Moreover, PA patients showed higher plasma PTH, lower serum 25(OH)-vitamin D levels, higher prevalence of vitamin D deficiency (65% versus 25% and 25%; P<0.001), and higher prevalence of osteopenia/osteoporosis (38.5 and 10.5%) than EH (28% and 4%) and NS (25% and 5%), respectively.
This study supports the hypothesis that bone loss and fracture risk in PA patients are potentially the result of aldosterone mediated hypercalciuria and the consecutive secondary hyperparathyroidism.
American Psychological Association (APA)
Petramala, Luigi& Zinnamosca, Laura& Settevendemmie, Amina& Cristiano, Marinelli& Nardi, Matteo& Concistrè, Antonio…[et al.]. 2014. Bone and Mineral Metabolism in Patients with Primary Aldosteronism. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036599
Modern Language Association (MLA)
Petramala, Luigi…[et al.]. Bone and Mineral Metabolism in Patients with Primary Aldosteronism. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036599
American Medical Association (AMA)
Petramala, Luigi& Zinnamosca, Laura& Settevendemmie, Amina& Cristiano, Marinelli& Nardi, Matteo& Concistrè, Antonio…[et al.]. Bone and Mineral Metabolism in Patients with Primary Aldosteronism. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036599