Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats
Joint Authors
Noal Moresco, Rafael
Roehrs, Miguel
Figueiredo, Cassieli Gehlen
Zanchi, Mariane Magalhães
Bochi, Guilherme Vargas
Quatrin, Andréia
Somacal, Sabrina
Conte, Lisiane
Emanuelli, Tatiana
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats.
Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin.
Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX.
BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity.
NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels).
These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state.
Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.
American Psychological Association (APA)
Roehrs, Miguel& Figueiredo, Cassieli Gehlen& Zanchi, Mariane Magalhães& Bochi, Guilherme Vargas& Noal Moresco, Rafael& Quatrin, Andréia…[et al.]. 2014. Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036600
Modern Language Association (MLA)
Roehrs, Miguel…[et al.]. Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036600
American Medical Association (AMA)
Roehrs, Miguel& Figueiredo, Cassieli Gehlen& Zanchi, Mariane Magalhães& Bochi, Guilherme Vargas& Noal Moresco, Rafael& Quatrin, Andréia…[et al.]. Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036600