Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice
Joint Authors
Zhou, Kequan
Fu, Yu
Luo, Jing
Jia, Zhenquan
Zhen, Wei
Liu, Dongmin
Gilbert, Elizabeth R.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion.
Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced glucose-stimulated insulin secretion (GSIS) in high-fat diet (HFD-) induced middle-aged obese mice.
Baicalein had no effect on food intake, body weight gain, circulating lipid profile, and insulin sensitivity in obese mice.
Using another mouse model of type 2 diabetes generated by high-fat diet (HFD) feeding and low doses of streptozotocin injection, we found that baicalein treatment significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in these middle-aged obese diabetic mice, which are associated with the improved islet β-cell survival and mass.
In the in vitro studies, baicalein significantly augmented GSIS and promoted viability of insulin-secreting cells and human islets cultured either in the basal medium or under chronic hyperlipidemic condition.
These results demonstrate that baicalein may be a naturally occurring antidiabetic agent by directly modulating pancreatic β-cell function.
American Psychological Association (APA)
Fu, Yu& Luo, Jing& Jia, Zhenquan& Zhen, Wei& Zhou, Kequan& Gilbert, Elizabeth R.…[et al.]. 2014. Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036602
Modern Language Association (MLA)
Fu, Yu…[et al.]. Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. International Journal of Endocrinology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1036602
American Medical Association (AMA)
Fu, Yu& Luo, Jing& Jia, Zhenquan& Zhen, Wei& Zhou, Kequan& Gilbert, Elizabeth R.…[et al.]. Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1036602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036602