Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation
Joint Authors
Lorenzo, O.
Fuentes-Antrás, J.
Ioan, A. M.
Tuñón, J.
Egido, Jesus
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic cardiomyopathy is defined as a ventricular dysfunction initiated by alterations in cardiac energy substrates in the absence of coronary artery disease and hypertension.
Hyperglycemia, hyperlipidemia, and insulin resistance are major inducers of the chronic low-grade inflammatory state that characterizes the diabetic heart.
Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF- κ B activation and ROS overproduction.
However, metabolic dysregulated factors such as peroxisome proliferator-activated receptors and sirtuins may serve as therapeutic targets to control this response by mitigating both Toll-like receptors and inflammasome signaling.
American Psychological Association (APA)
Fuentes-Antrás, J.& Ioan, A. M.& Tuñón, J.& Egido, Jesus& Lorenzo, O.. 2014. Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036603
Modern Language Association (MLA)
Fuentes-Antrás, J.…[et al.]. Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation. International Journal of Endocrinology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036603
American Medical Association (AMA)
Fuentes-Antrás, J.& Ioan, A. M.& Tuñón, J.& Egido, Jesus& Lorenzo, O.. Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036603