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Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
Joint Authors
Frühbeck, Gema
Gómez-Ambrosi, Javier
Pardo, María
Crujeiras, Ana B.
Amil, María
Aguera, Zaida
Baños, Rosa
de la Torre, Rafael
Estivill, Xavier
Fernández-Real, Jose M.
Fernández-García, José C.
Rodríguez, Roser
Tinahones, Francisco J.
Casanueva, Felipe F.
Cristina, Botella
Fagundo, Ana B.
Fernández-Aranda, Fernando
Jiménez-Murcia, Susana
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure.
However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects.
The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity.
The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW).
The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.
Irisin also correlated positively with body weight, BMI, and fat mass.
The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.
The irisin levels were inversely correlated with daily physical activity and directly correlated with REE.
Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters.
Conclusion.
Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
American Psychological Association (APA)
Pardo, María& Crujeiras, Ana B.& Amil, María& Aguera, Zaida& Jiménez-Murcia, Susana& Baños, Rosa…[et al.]. 2014. Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036606
Modern Language Association (MLA)
Pardo, María…[et al.]. Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036606
American Medical Association (AMA)
Pardo, María& Crujeiras, Ana B.& Amil, María& Aguera, Zaida& Jiménez-Murcia, Susana& Baños, Rosa…[et al.]. Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036606