The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats
Joint Authors
Lu, Bin
Shao, Jiaqing
Li, Jie
Peng, Li
Du, Hong
Wang, Yangtian
Xu, Yixin
Ye, Xiaozhen
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Objective.
To investigate the effect of beraprost sodium (BPS) on diabetic cardiomyopathy and the underlying mechanism.
Methods.
A total of 40 Sprague Dawley rats were randomly divided into the normal control group (N=10) and the model group (N=30).
The model group was fed a high-fat diet followed by a one-time dose of streptozotocin (STZ) to establish the diabetes mellitus model.
After that, rats were randomly divided into two groups with or without BPS intervention.
After 8 weeks, we explored the role of the p38 MAPK signaling pathway in inflammation, oxidative stress, cardiac morphology, and myocardial apoptosis.
Results.
Compared with control, the ratio of heart-weight to body-weight and the serum levels of SOD and GSH in the BPS group significantly increased, the expression of p38 MAPK, the serum levels of MDA, TGF-β1, TNF-α, HIF-1α, MMP-9, caspase-3, BNP, ANP, and heart Bax expression significantly decreased, and heart Bcl-2 expression significantly increased.
H&E staining in diabetic rats showed the cardiac muscle fibers derangement, the widening gap, the pyknotic and fragmented nuclei, and more apoptosis.
Conclusions.
BPS effectively showed protective effects on diabetic myocardial cells, possibly through the inhibition of p38 MAPK signaling pathway.
American Psychological Association (APA)
Li, Jie& Peng, Li& Du, Hong& Wang, Yangtian& Lu, Bin& Xu, Yixin…[et al.]. 2014. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036612
Modern Language Association (MLA)
Li, Jie…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1036612
American Medical Association (AMA)
Li, Jie& Peng, Li& Du, Hong& Wang, Yangtian& Lu, Bin& Xu, Yixin…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036612