The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats

Joint Authors

Lu, Bin
Shao, Jiaqing
Li, Jie
Peng, Li
Du, Hong
Wang, Yangtian
Xu, Yixin
Ye, Xiaozhen

Source

International Journal of Endocrinology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-11-10

Country of Publication

Egypt

No. of Pages

17

Main Subjects

Biology

Abstract EN

Objective.

To investigate the effect of beraprost sodium (BPS) on diabetic cardiomyopathy and the underlying mechanism.

Methods.

A total of 40 Sprague Dawley rats were randomly divided into the normal control group (N=10) and the model group (N=30).

The model group was fed a high-fat diet followed by a one-time dose of streptozotocin (STZ) to establish the diabetes mellitus model.

After that, rats were randomly divided into two groups with or without BPS intervention.

After 8 weeks, we explored the role of the p38 MAPK signaling pathway in inflammation, oxidative stress, cardiac morphology, and myocardial apoptosis.

Results.

Compared with control, the ratio of heart-weight to body-weight and the serum levels of SOD and GSH in the BPS group significantly increased, the expression of p38 MAPK, the serum levels of MDA, TGF-β1, TNF-α, HIF-1α, MMP-9, caspase-3, BNP, ANP, and heart Bax expression significantly decreased, and heart Bcl-2 expression significantly increased.

H&E staining in diabetic rats showed the cardiac muscle fibers derangement, the widening gap, the pyknotic and fragmented nuclei, and more apoptosis.

Conclusions.

BPS effectively showed protective effects on diabetic myocardial cells, possibly through the inhibition of p38 MAPK signaling pathway.

American Psychological Association (APA)

Li, Jie& Peng, Li& Du, Hong& Wang, Yangtian& Lu, Bin& Xu, Yixin…[et al.]. 2014. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036612

Modern Language Association (MLA)

Li, Jie…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1036612

American Medical Association (AMA)

Li, Jie& Peng, Li& Du, Hong& Wang, Yangtian& Lu, Bin& Xu, Yixin…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Cardiomyopathy through the Inhibition of the p38 MAPK Signaling Pathway in High-Fat-Induced SD Rats. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1036612

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1036612