Irisin Enhances Osteoblast Differentiation In Vitro
Joint Authors
Colucci, Silvia
Mongelli, Teresa
Mori, Giorgio
Cinti, Saverio
Cuscito, Concetta
Brunetti, Giacomina
Grano, Maria
Colaianni, Graziana
Oranger, Angela
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It has been recently demonstrated that exercise activity increases the expression of the myokine Irisin in skeletal muscle, which is able to drive the transition of white to brown adipocytes, likely following a phenomenon of transdifferentiation.
This new evidence supports the idea that muscle can be considered an endocrine organ, given its ability to target adipose tissue by promoting energy expenditure.
In accordance with these new findings, we hypothesized that Irisin is directly involved in bone metabolism, demonstrating its ability to increase the differentiation of bone marrow stromal cells into mature osteoblasts.
Firstly, we confirmed that myoblasts from mice subjected to 3 weeks of free wheel running increased Irisin expression compared to nonexercised state.
The conditioned media (CM) collected from myoblasts of exercised mice induced osteoblast differentiation in vitro to a greater extent than those of mice housed in resting conditions.
Furthermore, the differentiated osteoblasts increased alkaline phosphatase and collagen I expression by an Irisin-dependent mechanism.
Our results show, for the first time, that Irisin directly targets osteoblasts, enhancing their differentiation.
This finding advances notable perspectives in future studies which could satisfy the ongoing research of exercise-mimetic therapies with anabolic action on the skeleton.
American Psychological Association (APA)
Colaianni, Graziana& Cuscito, Concetta& Mongelli, Teresa& Oranger, Angela& Mori, Giorgio& Brunetti, Giacomina…[et al.]. 2014. Irisin Enhances Osteoblast Differentiation In Vitro. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036613
Modern Language Association (MLA)
Colaianni, Graziana…[et al.]. Irisin Enhances Osteoblast Differentiation In Vitro. International Journal of Endocrinology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036613
American Medical Association (AMA)
Colaianni, Graziana& Cuscito, Concetta& Mongelli, Teresa& Oranger, Angela& Mori, Giorgio& Brunetti, Giacomina…[et al.]. Irisin Enhances Osteoblast Differentiation In Vitro. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036613