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The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro
Joint Authors
Zhai, Yuan-Kun
Pan, Ya-Lei
Niu, Yin-Bo
Li, Chen-Rui
Wu, Xiang-Long
Fan, Wu-Tu
Lu, Ting-Li
Mei, Qi-Bing
Xian, Cory J.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Osteoporosis treatment always aimed at keeping the balance of bone formation and bone resorption.
Recently, prenyl group in natural products has been proposed as an active group to enhance the osteogenesis process.
Osthole has both the prenyl group and bone-protective activities, but the relationship is still unknown.
In this study we found that osthole exerted a potent ability to promote proliferation and osteogenic function of rat bone marrow stromal cells and osteoblasts, including improved cell viability, alkaline phosphatase activity, enhanced secretion of collagen-I, bone morphogenetic protein-2, osteocalcin and osteopontin, stimulated mRNA expression of insulin-like growth factor-1, runt-related transcription factor-2, osterix, OPG (osteoprotegerin), RANKL (receptor activator for nuclear factor-κB ligand), and the ratio of OPG/RANKL, as well as increasing the formation of mineralized nodules.
However, 7-methoxycoumarin had no obvious effects.
Osthole also inhibited osteoclastic bone resorption to a greater extent than 7-methoxycoumarin, as shown by a lower tartrate-resistant acid phosphatase activity and lower number and smaller area of resorption pits.
Our findings demonstrate that osthole could be a potential agent to stimulate bone formation and inhibit bone resorption, and the prenyl group plays an important role in these bone-protective effects.
American Psychological Association (APA)
Zhai, Yuan-Kun& Pan, Ya-Lei& Niu, Yin-Bo& Li, Chen-Rui& Wu, Xiang-Long& Fan, Wu-Tu…[et al.]. 2014. The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036622
Modern Language Association (MLA)
Zhai, Yuan-Kun…[et al.]. The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro. International Journal of Endocrinology No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1036622
American Medical Association (AMA)
Zhai, Yuan-Kun& Pan, Ya-Lei& Niu, Yin-Bo& Li, Chen-Rui& Wu, Xiang-Long& Fan, Wu-Tu…[et al.]. The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036622