Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions
Joint Authors
Wang, Xiangbing
Shapses, Sue A.
Yousefzadeh, Pegah
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial.
Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status.
The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to exert biological activity.
The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10–15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form.
While DBP is relatively stable in most healthy populations, a recent study showed that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity.
Furthermore, in some clinical situations, total vitamin D levels are altered and knowing whether DBP is also altered may have treatment implications.
The aim of this review is to assess DBP concentration in different physiological and pathophysiological conditions.
We suggest that DBP should be considered in the interpretation of 25(OH)D levels.
American Psychological Association (APA)
Yousefzadeh, Pegah& Shapses, Sue A.& Wang, Xiangbing. 2014. Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036636
Modern Language Association (MLA)
Yousefzadeh, Pegah…[et al.]. Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036636
American Medical Association (AMA)
Yousefzadeh, Pegah& Shapses, Sue A.& Wang, Xiangbing. Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036636