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Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach
Joint Authors
Lee, Hyun-Jeong
Park, Hye-Sun
Kim, Woonsu
Yoon, Duhak
Seo, Seongwon
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The interrelationship between muscle and adipose tissues plays a major role in determining the quality of carcass traits.
The objective of this study was to compare metabolic differences between muscle and intramuscular adipose (IMA) tissues in the longissimus dorsi (LD) of Hanwoo (Bos taurus coreanae) using the RNA-seq technology and a systems biology approach.
The LD sections between the 6th and 7th ribs were removed from nine (each of three cows, steers, and bulls) Hanwoo beef cattle (carcass weight of 430.2±40.66 kg) immediately after slaughter.
The total mRNA from muscle, IMA, and subcutaneous adipose and omental adipose tissues were isolated and sequenced.
The reads that passed quality control were mapped onto the bovine reference genome (build bosTau6), and differentially expressed genes across tissues were identified.
The KEGG pathway enrichment tests revealed the opposite direction of metabolic regulation between muscle and IMA.
Metabolic gene network analysis clearly indicated that oxidative metabolism was upregulated in muscle and downregulated in IMA.
Interestingly, pathways for regulating cell adhesion, structure, and integrity and chemokine signaling pathway were upregulated in IMA and downregulated in muscle.
It is thus inferred that IMA may play an important role in the regulation of development and structure of the LD tissues and muscle/adipose communication.
American Psychological Association (APA)
Lee, Hyun-Jeong& Park, Hye-Sun& Kim, Woonsu& Yoon, Duhak& Seo, Seongwon. 2014. Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036694
Modern Language Association (MLA)
Lee, Hyun-Jeong…[et al.]. Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach. International Journal of Genomics No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036694
American Medical Association (AMA)
Lee, Hyun-Jeong& Park, Hye-Sun& Kim, Woonsu& Yoon, Duhak& Seo, Seongwon. Comparison of Metabolic Network between Muscle and Intramuscular Adipose Tissues in Hanwoo Beef Cattle Using a Systems Biology Approach. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036694