Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain
Joint Authors
Xin, Aiguo
Zhu, Mingwang
Peng, Zhenqi
Hu, Qi
Shi, Chenhong
Liao, Defang
Wang, Jihua
Li, Huachun
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The molecular basis of attenuation of foot-and-mouth disease virus (FMDV) serotype Asia1 ZB strain remains unknown.
To understand the genetic changes of attenuation, we compared the entire genomes of three different rabbit-passaged attenuated ZB strains (ZB/CHA/58(att), ZBRF168, and ZBRF188) and their virulent parental strains (ZBCF22 and YNBS/58).
The results showed that attenuation may be brought about by 28 common amino acid substitutions in the coding region, with one nucleotide point mutation in the 5′-untranslated region (5′-UTR) and another one in the 3′-UTR.
In addition, a total of 21 nucleotides silent mutations had been found after attenuation.
These substitutions, alone or in combination, may be responsible for the attenuated phenotype of the ZB strain in cattle.
This will contribute to elucidation of attenuating molecular basis of the FMDV ZB strain.
American Psychological Association (APA)
Xin, Aiguo& Zhu, Mingwang& Peng, Zhenqi& Hu, Qi& Shi, Chenhong& Liao, Defang…[et al.]. 2014. Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036699
Modern Language Association (MLA)
Xin, Aiguo…[et al.]. Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain. International Journal of Genomics No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036699
American Medical Association (AMA)
Xin, Aiguo& Zhu, Mingwang& Peng, Zhenqi& Hu, Qi& Shi, Chenhong& Liao, Defang…[et al.]. Genomic Changes in an Attenuated ZB Strain of Foot-and-Mouth Disease Virus Serotype Asia1 and Comparison with Its Virulent Parental Strain. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036699