E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last
Joint Authors
Bogdanos, Dimitrios P.
Smyk, Daniel S.
Koutsoumpas, Andreas L.
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recurrent urinary tract infections (UTI) have been considered potential triggers of primary biliary cirrhosis (PBC), an autoimmune cholestatic liver disease characterised by progressive destruction of intrahepatic bile ducts.
Additional support for the link made between PBC and UTI was based on early observations of recurrent episodes of bacteriuria in female patients with PBC.
A series of large epidemiological studies demonstrated a strong correlation between recurrent UTI and PBC, initiating a series of studies investigating the role of Escherichia coli (E.
coli, the most prevalent organism isolated in women with UTI) as a trigger of PBC.
Immunological evidence of B- and T-cell cross-reactive responses implicating PBC-specific autoantigens and E.
coli mimics have been clearly demonstrated, adding support to the notion that E.
coli is a potential infectious inducer of PBC in susceptible individuals.
One of the major limitations in proving the E.
coli/PBC association was the lack of reliable E.
coli-infected animal models of PBC.
This review provides an overview of the evidence linking this infectious agent with PBC and discusses the pros and cons of a recently developed E.
coli-infected animal model of PBC.
American Psychological Association (APA)
Koutsoumpas, Andreas L.& Smyk, Daniel S.& Bogdanos, Dimitrios P.. 2014. E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036711
Modern Language Association (MLA)
Koutsoumpas, Andreas L.…[et al.]. E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last. International Journal of Hepatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036711
American Medical Association (AMA)
Koutsoumpas, Andreas L.& Smyk, Daniel S.& Bogdanos, Dimitrios P.. E. coli Induced Experimental Model of Primary Biliary Cirrhosis: At Last. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036711