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The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility
Joint Authors
Bushueva, Olga
Churnosov, Mikhail
Ivanov, Vladimir
Polonikov, Alexey V.
Solodilova, Maria A.
Source
International Journal of Hypertension
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute to essential hypertension (EH).
The present study was designed to investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in a Russian population.
A total of 2 995 unrelated subjects from Kursk (1 362 EH patients and 843 healthy controls) and Belgorod (357 EH patients and 422 population controls) regions of Central Russia were recruited for this study.
DNA samples from all study participants were genotyped for the FMO3 gene polymorphism through PCR followed by RFLP analysis.
We found that the polymorphism E158K is associated with increased risk of essential hypertension in both discovery population from Kursk region (OR 1.36 95% CI 1.09–1.69, P = 0.01 ) and replication population from Belgorod region (OR 1.54 95% CI 1.07–1.89, P = 0.02 ) after adjustment for gender and age using logistic regression analysis.
Further analysis showed that the increased hypertension risk in carriers of genotype 158KK gene occurred in cigarette smokers, whereas nonsmoker carriers of this genotype did not show the disease risk.
This is the first study reporting the association of the FMO3 gene polymorphism and the risk of essential hypertension.
American Psychological Association (APA)
Bushueva, Olga& Solodilova, Maria A.& Churnosov, Mikhail& Ivanov, Vladimir& Polonikov, Alexey V.. 2014. The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility. International Journal of Hypertension،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036718
Modern Language Association (MLA)
Bushueva, Olga…[et al.]. The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility. International Journal of Hypertension No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1036718
American Medical Association (AMA)
Bushueva, Olga& Solodilova, Maria A.& Churnosov, Mikhail& Ivanov, Vladimir& Polonikov, Alexey V.. The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility. International Journal of Hypertension. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1036718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036718