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Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine
Joint Authors
Gouvea, Sonia Alves
Tiradentes, Renata V.
Santuzzi, Cintia H.
Mengal, Vinícius
Futuro Neto, Henrique de A.
Silva, Nyam F.
Abreu, Gláucia R.
Source
International Journal of Hypertension
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The purpose was to determine the role of renal nerves in mediating the effects of antihypertensive treatment with L-arginine in a renovascular hypertension model.
The 2K1C (two-kidney one-clip model) hypertensive rats were submitted to bilateral surgical-pharmacological renal denervation.
The animals were subdivided into six experimental groups: normotensive control rats (SHAM), 2K1C rats, 2K1C rats treated with L-arginine (2K1C + L-arg), denervated normotensive (DN) rats, denervated 2K1C (2K1C + DN) rats, and denervated 2K1C + L-arg (2K1C + DN + L-arg) rats.
Arterial blood pressure, water intake, urine volume, and sodium excretion were measured.
The 2K1C rats exhibited an increase in the mean arterial pressure (MAP) (from 106 ± 3 to 183 ± 5.8 mmHg, P<0.01), whereas L-arg treatment induced a reduction in the MAP (143 ± 3.4 mmHg) without lowering it to the control level.
Renal nerve denervation reduced the MAP to normotensive levels in 2K1C rats with or without chronic L-arg treatment.
L-arg and denervation induced increases in water intake and urine volume, and L-arg caused a significant natriuretic effect.
Our results suggest that renal sympathetic activity participates in the genesis and the maintenance of the hypertension and also demonstrate that treatment with L-arg alone is incapable of normalizing the MAP and that the effect of such treatment is not additive with the effect of kidney denervation.
American Psychological Association (APA)
Gouvea, Sonia Alves& Tiradentes, Renata V.& Santuzzi, Cintia H.& Mengal, Vinícius& Futuro Neto, Henrique de A.& Silva, Nyam F.…[et al.]. 2014. Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine. International Journal of Hypertension،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036719
Modern Language Association (MLA)
Gouvea, Sonia Alves…[et al.]. Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine. International Journal of Hypertension No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036719
American Medical Association (AMA)
Gouvea, Sonia Alves& Tiradentes, Renata V.& Santuzzi, Cintia H.& Mengal, Vinícius& Futuro Neto, Henrique de A.& Silva, Nyam F.…[et al.]. Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine. International Journal of Hypertension. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036719