Quantifying Proteinuria in Hypertensive Disorders of Pregnancy
Joint Authors
Hebbar, Shripad
Kumar, Pratap
Rai, Lavanya
Illipilla, Sireesha
Amin, Sapna Vinit
Pai, Murlidhar V.
Source
International Journal of Hypertension
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Progressive proteinuria indicates worsening of the condition in hypertensive disorders of pregnancy and hence its quantification guides clinician in decision making and treatment planning.
Objective.
To evaluate the efficacy of spot dipstick analysis and urinary protein-creatinine ratio (UPCR) in hypertensive disease of pregnancy for predicting 24-hour proteinuria.
Subjects and Methods.
A total of 102 patients qualifying inclusion criteria were evaluated with preadmission urine dipstick test and UPCR performed on spot voided sample.
After admission, the entire 24-hour urine sample was collected and analysed for daily protein excretion.
Dipstick estimation and UPCR were compared to the 24-hour results.
Results.
Seventy-eight patients (76.5%) had significant proteinuria of more than 300 mg/24 h.
Dipstick method showed 59% sensitivity and 67% specificity for prediction of significant proteinuria.
Area under curve for UPCR was 0.89 (95% CI: 0.83 to 0.95, P < 0.001 ) showing 82% sensitivity and 12.5% false positive rate for cutoff value of 0.45.
Higher cutoff values (1.46 and 1.83) predicted heavy proteinuria (2 g and 3 g/24 h, resp.).
Conclusion.
This study suggests that random urinary protein : creatine ratio is a reliable investigation compared to dipstick method to assess proteinuria in hypertensive pregnant women.
However, clinical laboratories should standardize the reference values for their setup.
American Psychological Association (APA)
Amin, Sapna Vinit& Illipilla, Sireesha& Hebbar, Shripad& Rai, Lavanya& Kumar, Pratap& Pai, Murlidhar V.. 2014. Quantifying Proteinuria in Hypertensive Disorders of Pregnancy. International Journal of Hypertension،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036721
Modern Language Association (MLA)
Amin, Sapna Vinit…[et al.]. Quantifying Proteinuria in Hypertensive Disorders of Pregnancy. International Journal of Hypertension No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036721
American Medical Association (AMA)
Amin, Sapna Vinit& Illipilla, Sireesha& Hebbar, Shripad& Rai, Lavanya& Kumar, Pratap& Pai, Murlidhar V.. Quantifying Proteinuria in Hypertensive Disorders of Pregnancy. International Journal of Hypertension. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036721