Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages
Joint Authors
Weber, Kassandra
Schilling, Joel
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lysosomes play a critical role in the degradation of both extracellular and intracellular material.
These dynamic organelles also contribute to nutrient sensing and cell signaling pathways.
Macrophages represent a heterogeneous group of phagocytic cells that contribute to tissue homeostasis and inflammation.
Recently, there has been a renewed interest in understanding the role of macrophage autophagy and lysosome function in health and disease.
Thioglycollate-elicited peritoneal and bone marrow-derived macrophages are commonly used ex vivo systems to study primary macrophage function.
In this study, we reveal dramatic baseline differences in the lysosome morphology and function between these macrophage populations and provide evidence that these differences can be functionally relevant.
Our results provide important insights into the diversity of lysosomes in primary macrophages and illustrate the importance of accounting for this in data interpretation.
American Psychological Association (APA)
Weber, Kassandra& Schilling, Joel. 2014. Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036723
Modern Language Association (MLA)
Weber, Kassandra& Schilling, Joel. Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages. International Journal of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036723
American Medical Association (AMA)
Weber, Kassandra& Schilling, Joel. Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036723