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Hemoglobin Expression in Nonerythroid Cells: Novel or Ubiquitous?
Joint Authors
Saha, Debarchana
Patgaonkar, Mandar
Shroff, Ankit
Ayyar, Kanchana
Bashir, Tahir
Reddy, K. V. R.
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hemoglobin (Hb) is a major protein involved in transport of oxygen (O2).
Red blood cells (RBCs) contain maximum amount of Hb and because of their unique structure and plasticity they transport O2 to various tissues of the body at an optimal concentration.
Recently, it has been reported that, apart from RBCs, Hb is also expressed by nonerythroid cells such as epithelial cells of different origin.
The cells expressing Hb are from the tissues where maintenance of O2 homeostasis is of paramount importance.
Hb expression has been observed in the epithelial cells from human tissues including lungs, neurons, retina, and endometrium.
Our group has recently demonstrated that Hb is expressed by the cervicovaginal epithelial cells.
We further showed that, apart from maintaining O2 homeostasis, Hb and the peptides derived from it play an indispensable role in the protection of vaginal epithelium by exhibiting antimicrobial activity.
In this review, we discuss the significance of Hb expression in vaginal epithelial cells and its role in the recognition of pathogens thereby reducing the risk and/or severity of inflammation and/or infections and the possible mechanism by which Hb exhibits antimicrobial and antioxidative functions.
American Psychological Association (APA)
Saha, Debarchana& Patgaonkar, Mandar& Shroff, Ankit& Ayyar, Kanchana& Bashir, Tahir& Reddy, K. V. R.. 2014. Hemoglobin Expression in Nonerythroid Cells: Novel or Ubiquitous?. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036727
Modern Language Association (MLA)
Saha, Debarchana…[et al.]. Hemoglobin Expression in Nonerythroid Cells: Novel or Ubiquitous?. International Journal of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036727
American Medical Association (AMA)
Saha, Debarchana& Patgaonkar, Mandar& Shroff, Ankit& Ayyar, Kanchana& Bashir, Tahir& Reddy, K. V. R.. Hemoglobin Expression in Nonerythroid Cells: Novel or Ubiquitous?. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036727