Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C
Joint Authors
Yamamoto, Kazuhide
Takaki, Akinobu
Yagi, Takahito
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Hepatitis B and C often progress to decompensated liver cirrhosis requiring orthotopic liver transplantation (OLT).
After OLT, hepatitis B recurrence is clinically controlled with a combination of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogues.
Another approach is to induce self-producing anti-hepatitis B virus (HBV) antibodies using a HBV envelope antigen vaccine.
Patients who had not been HBV carriers such as acutely infected liver failure or who received liver from HBV self-limited donor are good candidate.
For chronic HBV carrier patients, a successful response can only be achieved in selected patients such as those treated with experimentally reduced immunosuppression protocols or received an anti-HBV adaptive memory carrying donor liver.
Hepatitis C virus (HCV) reinfects transplanted livers at a rate of >90%.
HCV reinfected patients show different severities of hepatitis, from mild and slowly progressing to severe and rapidly progressing, possibly resulting from different adaptive immune responses.
More than half the patients require interferon treatment, although the success rate is low and carries risks for leukocytopenia and rejection.
Managing the immune response has an important role in controlling recurrent hepatitis C.
This study aimed to review the adaptive immune response in post-OLT hepatitis B and C.
American Psychological Association (APA)
Takaki, Akinobu& Yagi, Takahito& Yamamoto, Kazuhide. 2014. Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036729
Modern Language Association (MLA)
Takaki, Akinobu…[et al.]. Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C. International Journal of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1036729
American Medical Association (AMA)
Takaki, Akinobu& Yagi, Takahito& Yamamoto, Kazuhide. Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036729