Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees
Joint Authors
Magden, Elizabeth R.
Hanley, Patrick W.
Abee, Christian R.
Nehete, Pramod N.
Nehete, Bharti
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obesity is characterized by chronic low-grade inflammation and serves as a major risk factor for hypertension, coronary artery disease, dyslipidemias, and type-2 diabetes.
The purpose of this study was to examine changes in metabolic hormones, inflammatory cytokines, and immune function, in lean, overweight, and obese chimpanzees in a controlled environment.
We observed increased plasma circulating levels of proinflammatory TH-1 cytokines, Interferon gamma, interleukin-6, interleukin-12p40, tumor necrosis factor, soluble CD40 ligand, and Interleukin-1 β and anti-inflammatory TH-2 cytokines, Interleukin-4, Interleukin-RA, Interleukin-10, and Interleukin-13 in overweight and obese chimpanzees.
We also observed increased levels of metabolic hormones glucagon-like-peptide-1, glucagon, connecting peptide, insulin, pancreatic peptide YY3–36, and leptin in the plasma of overweight and obese chimpanzees.
Chemokine, eotaxin, fractalkine, and monocyte chemoattractant protein-1 were higher in lean compared to obese chimpanzees, while chemokine ligand 8 increased in plasma of obese chimpanzees.
We also observed an obesity-related effect on immune function as demonstrated by lower mitogen induced proliferation, and natural killer activity and higher production of IFN- γ by PBMC in Elispot assay, These findings suggest that lean, overweight, and obese chimpanzees share circulating inflammatory cytokines and metabolic hormone levels with humans and that chimpanzees can serve as a useful animal model for human studies.
American Psychological Association (APA)
Nehete, Pramod N.& Magden, Elizabeth R.& Nehete, Bharti& Hanley, Patrick W.& Abee, Christian R.. 2014. Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036730
Modern Language Association (MLA)
Nehete, Pramod N.…[et al.]. Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees. International Journal of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036730
American Medical Association (AMA)
Nehete, Pramod N.& Magden, Elizabeth R.& Nehete, Bharti& Hanley, Patrick W.& Abee, Christian R.. Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036730