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Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan
Joint Authors
Muneta, Takeshi
Sekiya, Ichiro
Yamada, Jun
Miyatake, Kazumasa
Matsukura, Yu
Abula, Kahaer
Inoue, Makiko
Tsuji, Kunikazu
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Activins are proinflammatory cytokines which belong to the TGFβ superfamily.
Follistatin is an extracellular decoy receptor for activins.
Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration.
To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model.
Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin.
Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin.
In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage.
These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis.
Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration.
American Psychological Association (APA)
Yamada, Jun& Tsuji, Kunikazu& Miyatake, Kazumasa& Matsukura, Yu& Abula, Kahaer& Inoue, Makiko…[et al.]. 2014. Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036732
Modern Language Association (MLA)
Yamada, Jun…[et al.]. Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan. International Journal of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036732
American Medical Association (AMA)
Yamada, Jun& Tsuji, Kunikazu& Miyatake, Kazumasa& Matsukura, Yu& Abula, Kahaer& Inoue, Makiko…[et al.]. Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036732